Myer originally opened in Dandenong on November 4, 1974 as a four-level, standalone department store, with the Capital Centre opening in 1989. In the 1990's the Dandenong Plaza development, joining Myer to the Capital Centre, saw Myer reduce from four to three levels.
In late 2013, Myer closed it's store in Dandenong, leaving the space to be fully renovated into the Dandenong Plaza. Target now occupies the former ground floor opening into Dandenong Plaza. with varying other stores including Aldi occupying the upper floors.